After the successful development of its first range of dermocosmetic products (sold under the brand Lhov), our team developed a dermocosmetic ingredient, the gold nanoflowers. Combined with light therapy, these cosmetic ingredient will help the recovering of damaged and sensitized skins.

In health projects, gold nanoparticles are greenly produced using plant extract from Reunion Island. For the development of dermocosmetic formulations, a novel ingredient was created, called nanoflowers, which consists in 50nm sized gold nanoparticles. They are not absorbed through the skin but form a protective barrier. These cosmetics have already gone through intensive toxicity assays and show a protective effect of the skin through anti-oxidant and anti-apoptotic activities. All these activities are essential for a skin to recover and to be protected after damage like radiotherapy can cause.

Gold nanoflower

Gold nanoflower are not absorbed through the skin

Antioxidant activity by DPPH method measured on GAuNP
Antioxidant activity by DPPH method measured on CAuNP

Antioxidant activity by DPPH method measured on GAuNP (image 1) and CAuNP (image 2) | Results are expressed as mean ± SD (n=3)

About the graphs (antioxidant test): The percentage of antioxidant activity was assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay. This method is based upon the change in color of DPPH solution from violet to pale yellow when this stable free radical converts into its reduced form by the reaction of a substance capable of donating hydrogen atoms.

Effects of AuNP on UV-A induced MMP-1 production

Effects of AuNP on UV-A induced MMP-1 production

About the graph (anticollagenase activity): The assay was based on the evaluation of matrix metalloproteinase 1 (MMP-1 or collagenase) production by NHDF culture in the absence or presence of the GAuNP and exposed to UV-A.

The Nanoflower program was funded by the regional PIA3 and the committee Alizés from Initiative entreprendre.

Patent: European patent granted – gold nanoparticles and ecological mehtod of production- EP 3 405 304 B1