Nuclear imaging is the reference molecular imaging tool. A non-invasive technique with a very high sensitivity, it allows in vivo studies of physiological, biochemical and molecular processes. Complementary to more morphological imaging techniques such as radiology, ultrasound or MRI, it provides functional and metabolic data. Widely used in clinical practice, it is also an extremely effective research tool.
Our partner has a state-of-the-art preclinical imaging tool dedicated to small animals. This scanner has several modalities: PET (Positron Emission Tomography) and SPECT (Single Photon Emission Tomography) imaging for monitoring radiotracers; and also an X-ray scanner for obtaining anatomical images. The acquisitions obtained by the three modalities of the device are reconstructed to give dynamic images of a very high precision.
Several studies can be conducted on this device. In the case of new radiotracers, the evaluation of their biodistribution (mapping of the distribution of the molecule in the body) and their pharmacokinetics (study of the fate of the molecule in the body over time) is carried out on the preclinical scanner. The results obtained thus make it possible to conclude on the diagnostic potential of the radiotracer studied on a pathology.
This imaging tool can also be used to evaluate the therapeutic effectiveness of new molecules using validated radiotracers used in nuclear medicine.
It allows to monitor some pathologies like cancer, bone destruction thanks to clinical tracers like 18F-FDG, 99mTc-MDP, 18F-NaF. But it is also possible to label your test item with radioisotopes in order to study their biodistribution after in vivo injection. Indeed, a radiochemistry unit is attached to this imaging unit. It is possible to label molecules with 18F, 68Ga and 99mTc.
Our partner has the necessary tools to carry out the different stages of the development of a radiopharmaceutical: choice of the target to be explored, synthesis of the molecule, radiolabeling, biological evaluation. Imaging protocols in animal experiments are strictly controlled by an ethics committee.